Principle of Cell Capacitance Technology
Cells with intact plasma membranes can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build up of charge. The resulting capacitance can be measured: it is dependent upon the cell type and is directly proportional to the membrane bound volume of these viable cells.
The capacitance (pF/cm) that the measures can easily be converted into other units such as cells/ml, g/L etc. Other units can also be derived from the raw capacitance measurements
Also measures the Conductivity of the medium, in millisiemens per centimeter (mS/cm). Conductivity is not used to measure biomass but is indicative of the production or utilization of ions by the cell suspension. The ABER system & probe provides an electrical field and measures LIVE cell concentration online.
Cell culture process development and manufacturing
Aber Instruments’ technology can be applied to in both R&D and manufacturing processes to monitor:
Suspension cell
Micro-carrier culture and packed beds
Cell culture – Manufacturing
Controlling constant cell concentrations
Microbial applications
And, equally our technology is successfully deployed in microbial applications to meausre:
Bacterial fermentations
High density yeast fermentations
Pichia fermentations
Mycelial fermentations
