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Principle of Cell Capacitance Technology

Cells with intact plasma membranes can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build up of charge. The resulting capacitance can be measured: it is dependent upon the cell type and is directly proportional to the membrane bound volume of these viable cells.

The capacitance (pF/cm) that the measures can easily be converted into other units such as cells/ml, g/L etc. Other units can also be derived from the raw capacitance measurements

Also measures the Conductivity of the medium, in millisiemens per centimeter (mS/cm). Conductivity is not used to measure biomass but is indicative of the production or utilization of ions by the cell suspension. The ABER system & probe provides an electrical field and measures LIVE cell concentration online.

Cell culture process development and manufacturing

Aber Instruments’ technology can be applied to in both R&D and manufacturing processes to monitor:

Suspension cell

Micro-carrier culture and packed beds

Cell culture – Manufacturing

Controlling constant cell concentrations

 

Microbial applications

And, equally our technology is successfully deployed in microbial applications to meausre:

Bacterial fermentations

High density yeast fermentations

Pichia fermentations

Mycelial fermentations